Top 50 Most Promising Digital Healthcare Startups of 2025

Innovative Startups Shaping Healthcare’s Future Today
Top 50 Most Promising Digital Healthcare Startups of 2025.jpg
Written By:
Srinivas
Reviewed By:
Sankha Ghosh
Published on

The digital health revolution is accelerating at an unprecedented pace, transforming how we diagnose diseases, deliver care, and manage wellness. From AI-powered diagnostic tools to remote patient monitoring platforms, innovative startups are solving healthcare's most pressing challenges improving access, reducing costs, and enabling precision medicine at scale.

This comprehensive guide showcases 50 groundbreaking digital health companies leading the charge in 2025. Spanning AI diagnostics, telehealth, mental health tech, genomics, administrative automation, and specialty care, these startups represent the future of healthcare, where technology meets compassion to create better outcomes for patients and providers alike.

1. PathAI

Headquarter: Massachusetts, United States

Founded in: 2016

Key Products: PathExplore™, PathExplore™ IOP, IHC Explore™, PathExplore™ Fibrosis, AIM-PD-L1, AIM-HER2 Breast Cancer, AIM-IHC Breast Panel, Real-World Data (RWD), AIM-MASH / AIM-MASH+, Liver Explore, AIM-HI Ulcerative Colitis and IBD Explore

Website: Click Here

PathAI offers AI-powered pathology solutions with the aim of improving diagnostic accuracy, speeding up drug development, and giving pathologists and researchers access to tools for digital analysis of medical images. The technology that PathAI uses enhances productivity, makes it easier to conduct biomarker quantification according to a standard, and supports the development of precision medicine which is already more advanced in biopharma, labs, and clinicians.

2. Tempus Labs

Headquarters: Illinois, United States

Founded in: 2015

Key Products: Tempus xT Platform, Pan-cancer Tumor Organoid (TO) Platform, Liquid Biopsy Assay, David (Generative AI Co-Pilot) and Tempus ECG-Low EF Software

Website: Click Here

Tempus Labs is a ground-breaking health tech enterprise that makes use of AI and data to accelerate the adoption of precision medicine. The company started with a focus on cancer but has since moved to other areas such as brain diseases, heart diseases, infections, and radiology. Real-time healthcare data is being used to allow physicians to customize the diagnostic and treatment protocols which will in turn ensure that patients get and enjoy the most effective care resulting in better outcomes.

3. Rad AI

Headquarters: San Francisco, United States

Founded in: 2018

Key Products: Rad AI Reporting, Rad AI Impressions, Rad AI Continuity, and a Resource Hub

Website: Click Here

Rad AI is revolutionizing radiology by integrating advanced AI to support physicians and health systems. Using proprietary generative AI models and one of the largest radiology report datasets, it streamlines workflows, reduces burnout, and enhances patient care. By automating repetitive tasks and providing intelligent insights, Rad AI empowers radiologists to focus on critical decision-making, improving efficiency, accuracy, and the overall quality of healthcare delivery.

4. Anumana

Headquarters: Massachusetts, United States

Founded in: 2021

Key Products: ECG-AI™ LEF, ECG Viewer, ECG-AI Panel, Peri-Procedure Software Solutions, Purpose-Built Data Platform, Multi-Dimensional Structured Data, ECG-AI Algorithm and Workflow Integration with EHR

Website: Click Here

Anumana is a company that is changing the world of cardiac care by utilizing state-of-the-art AI, which is able to convert intricate heart signals into practical information. By capitalizing on enormous patient data sets and the high-tech algorithms like ECG-AI™, it makes possible the earlier detection of unsuspected cardiovascular conditions, and gives doctors the power of making smarter decisions, and ultimately, the whole cardiac interventions are changed, speedy, accurate, and life-saving.

 5. GeneDx Holdings Corp

Headquarters: Connecticut, United States

Founded in: 2000

Key Products: Rare Disease Genetic Tests, Hereditary Cancer Panels, Neurology Panels, Cardiology Panels, and Pharmacogenomics Tests

Website: Click Here

GeneDx Holdings Corp. delivers state-of-the-art genetic testing for rare ailments, hereditary cancer, and issues related to the nervous system, heart, and drugs. The firm provides health practitioners and patients with geno-mic insights that can be acted upon hence allowing for timely diagnosis and customized treatment. By using the latest in technology, GeneDx gives out accurate, trustworthy results, and has among its customers clinical laboratories, universities, and healthcare systems all around the world.

6. Paige AI

Headquarters: New York, United States

Founded in: 2004

Key Products: Paige Platform, Paige Alba™, Paige Prostate Suite, Paige Breast Suite, Paige GI Suite, Paige PanCancer Detect, and Paige OmniScreen™

Website: Click Here

Paige.AI is a company that deals in the digital health tech domain and specializes in artificial intelligence-based solutions for pathology and oncology. Furthermore, it also provides cutting-edge platforms and tools to pathologists to analyze medical images, clinical and genomic data integration and also the boost in diagnostic accuracy. The adoption of AI along with the expert insights results in Paige.AI not only enhancing efficiency but also supporting precision medicine and global patient care.

7. Binah.ai

Headquarters: Boston, United States

Founded in: 2016

Key Products: Health Data Platform, Binah SDK, Binah Check, Binah Connect App, Health Indicators, Wellness Score, Technology Solutions for Insurance, Wellness, and Healthcare & Pharma.

Website: Click Here

Binah.ai is the one behind the AI technology that is using non-invasive, contactless ways for watching vital signs. The main characteristic of its platform is that it gives readings of the heart rate, oxygen saturation, respiration, heart rate variability, and stress levels, using just the video of the user’s face. This health monitor is capable of serving patients, clinicians, and businesses, and through the work of Binah.ai, individuals get access to health insights that are real-time, accurate, and of medical-grade quality, all these without the need for wearables or extra devices.

8. Gestalt Diagnostics

Headquarters: Washington, United States 

Founded in: 2015

Key Products: PathFlow® AP, PathFlow® Education, PathFlow® Research, PathCloud®, Health Data Cloud, AI Custom Solutions, AI and Machine Learning, LIS Archive & Migration, Reportable Disease & Cancer Reporting (ELR), Physician Lab Portal, AIRE AI Requisition Engine, Interfaces & Interoperability.

Website: Click Here

Gestalt Diagnostics is pushing the dike of anatomic pathology by transforming lab workflows into a digitalized way. The firm helps in the clinical and research areas by focusing on increasing efficiency, accuracy, and collaboration. By bringing in smart technologies and the efficient practices, Gestalt not only improves the diagnostics capabilities but also supports the healthcare providers and plays the role of innovator in pathology that results in the better outcome of patients.

9. Hippocratic AI

Headquarters: California, United States

Founded in: 2023

Key Products: Hippocratic AI Co-pilot App, Solutions for  Quality Improvement, Care Management, Readmission Prevention, Health Equity, and Compliance

Website: Click Here

Hippocratic AI revolutionizes healthcare with its AI-powered Co-pilot App, addressing the global shortage of healthcare workers. By focusing on patient safety, superior outcomes, and equal access, its generative AI assists clinicians, enhances workflow efficiency, and supports smarter, faster, and more compassionate care. This innovative approach ensures healthcare abundance and improved experiences for patients worldwide.

10. 1m 

Headquarters: New York, United States

Founded in: 2022

Key Products: ARIA, Helm, Radar, 1m Intelligence Network

Website: Click Here

1m is a data and analytics technology company that provides a risk management and performance platform within the healthcare sector. The company offers an integrated solution for enterprise risk, internal audit, and compliance teams, designed to unify these functions into a cohesive risk management program. It primarily serves the healthcare industry, providing tools and services that support risk assessment, threat identification, and strategic decision-making. 

11. Doctolib

Headquarters: Paris, France

Founded in: 2013

Key Products: Doctolib Operating System (OS) for healthcare professionals, AI Consultation Assistant, Teleconsultations and Patient Health Companion

Website: Click Here

Doctolib is revolutionizing healthcare by blending technology and AI to make life easier for both health professionals and patients. Its smart platform reduces administrative burdens, powers AI-driven consultations, and boosts telehealth access, allowing clinicians to focus on what matters most, delivering personalized, preventive, and high-quality care while keeping patients healthier, happier, and empowered.

12. Hinge Health

Headquarters: San Francisco, United States

Founded in: 2014

Key Products: Virtual Physical Therapy, Wearable Sensors, Behavioral Health Coaching, AI-powered Movement Analysis and Robin care assistant
Website: Click Here

Hinge Health transforms muscle and joint pain management by delivering expert care through a smart app. The platform provides personalized exercise therapy, real-time AI feedback, and guidance from licensed physical therapists and health coaches, all accessible from home. Fully covered by employers or insurance, it offers convenient, effective, and accessible pain relief solutions.

13. Zocdoc

Headquarters: New York, United States

Founded in: 2007

Key Products: Zocdoc App, Zocdoc AI Phone Assistant (Zo), Zocdoc Enterprise Solutions, Zocdoc for Developers, Provider Directories, Insurance Carrier Directories and EHR partnership solutions.

Website: Click Here

Zocdoc is revolutionizing healthcare by giving patients the power to find and book the right providers quickly, access verified reviews, and view transparent costs, all in one platform. By streamlining scheduling and reducing administrative burdens, Zocdoc allows doctors to focus on delivering care while expanding their practice. Its patient-first approach creates a seamless, efficient, and accessible healthcare experience for everyone.

14. Halodoc

Headquarters: Jakarta, Indonesia

Founded in: 2016

Key Products: Teleconsultation Service, Medicine Delivery, Lab Services, Premium Hospital Appointments and Advanced Search Engine

Website: Click Here

Halodoc is transforming healthcare access in Indonesia by connecting patients, medical professionals, and facilities through a seamless digital platform. Committed to innovation and reliability, the company focuses on improving patient experiences, streamlining healthcare processes, and ensuring efficient, accessible, and high-quality medical services across the nation.

15. Sprinter Health

Headquarters: California, United States

Founded in: 2021

Key Products: In-home and Virtual Preventive Care, Care Gap Closure and Wellness Visits, Diagnostics Services, Medication support and Care navigation

Website: Click Here

Sprinter Health is transforming healthcare by delivering high-quality, personalized care directly to patients’ homes. Combining in-home visits with advanced technology, their hybrid model enhances access, closes care gaps, and strengthens patient engagement. Focused on innovation and scale, Sprinter Health empowers both patients and providers, ensuring healthcare is convenient, proactive, and centered on individual needs.

16. Neko Health

Headquarters: Stockholm, Sweden

Founded in: 2018

Key Products: Neko Body Scan, Preventive Healthcare Services, Health Data Analysis, Diagnostic Health Centers, Clinical Studies

Website: Click Here

Neko Health is transforming healthcare by focusing on prevention and early detection. The company combines advanced body scans, AI analysis, and in-house medical expertise to detect potential health risks. By integrating hardware, software, and clinics, Neko aims to make proactive, data-driven healthcare accessible, efficient, and affordable for everyone.

17. Function Health

Headquarters: Texas, United States

Founded in: 2022

Key Products: Annual Lab Tests, Follow-up Tests, Doctor Insights, Clinician Summaries, Multi-Cancer Early Detection

Website: Click Here

Function Health redefines wellness by combining advanced lab testing with expert medical insights. Shifting healthcare from reactive to proactive, it emphasizes prevention, personalized guidance, and data privacy. The approach enables deep understanding of the body, supporting healthier, more vibrant living through actionable health insights and tailored wellness strategies.

18. Delfina

Headquarters:  San Francisco, California

Founded in: 2021

Key Products: Delfina Care Platform, Personalized Care Plans, Patient Mobile App, Provider Dashboard, Remote Patient Monitoring (RPM), Doula Support

Website: Click Here

Delfina empowers families with a patient-centric, AI-driven maternal health platform. By combining continuous remote monitoring, personalized support, and culturally adaptive care, Delfina closes gaps in prenatal and postpartum care. Focused on improving outcomes, reducing costs, and supporting providers, the platform ensures every pregnancy journey is safe, informed, and fully supported from start to finish.

19. Nourish Care Systems

Headquarters: Bournemouth, United Kingdom 

Founded in: 2011

Key Products: Nourish Better Care, Nourish Better Care at Home, Nourish Empower, Nourish Safety, Nourish Transparency, Nourish Insights, Nourish eLearning, and Nourish Protect.

Website: Click Here

Nourish is a person-centered long-term care platform that simplifies care management. Its digital tools enable better collaboration, faster care alignment, and improved outcomes, supporting care workers, managers, and organizations to deliver efficient, community-centered, and high-quality services for everyone connected to their care ecosystem.

20. Practo

Headquarters: Bengaluru, India

Founded in: 2008

Key Products: Instant Video Consultation, Doctor and Clinic Search, In-Clinic Appointment Booking, Lab Tests, and Private Online Consultations.

Website: Click Here

Practo is revolutionizing healthcare in India by making quality medical services accessible and affordable. Through verified doctor directories, online consultations, appointment bookings, diagnostic services, and medicine delivery, Practo empowers patients to make informed health decisions. With advanced practice management tools and subscription health plans, it fosters trust, transparency, and continuous care for millions across the country and beyond.

21. Lyra Health

Headquarters: California, United States 

Founded in: 2015

Key Products: Evidence-Based Therapy, AI-Powered Care Matching, Real-Time Support, Self-Care Tools, Workforce Strategy Consultations, Educational Resources, Peer-Led Program Support, Crisis Assistance, Lyra App, Centers of Excellence, Organizational Mental Health Solutions.

Website: Click Here

Lyra Health is revolutionizing mental health care by combining expert providers, advanced technology, and a commitment to quality. Founded to tackle the global mental health access gap, Lyra empowers employees and organizations with evidence-based therapy, real-time support, and innovative workforce solutions, improving well-being, productivity, and reducing costs while transforming how people access mental health services worldwide.

22. Iona Mind

Headquarters: Romford, England

Founded in: 2019

Key Products: Iona Mind Platform, Tailored Psychological Support, Behavioral Health Programs, Mental Health Support for Chronic Diseases

Website: Click Here

Iona Mind transforms mental health support by creating personalized, scalable solutions that truly fit your population’s needs. Collaborating directly with patients, they deliver inclusive, evidence-based programs for chronic diseases and underrepresented groups. With 24/7 support and globally recognized, market-leading approaches, Iona Mind makes mental well-being accessible, engaging, and effective for everyone.

23. MentalHappy

Headquarters: San Francisco, United States 

Founded in:  2016

Key Products: MentalHappy Platform, Professionally-Led Support Groups

Website: Click Here

MentalHappy transforms emotional support by providing a safe, inclusive space for everyone. It offers free resources and expert-led support groups, designed to overcome traditional barriers. By connecting communities and empowering organizations, MentalHappy strengthens well-being, fosters meaningful connections, and makes mental health support engaging, accessible, and impactful for people across the globe.

24. HealthEx

Headquarters: San Francisco, United States

Founded in: 2022

Key Products: Patient Consent Management, Real-time Health Record Access, AI-driven Data Rights Management and Care Management

Website: Click Here

HealthEx is a patient-focused digital healthcare platform that enables secure, compliant, and AI-powered management of health data. It streamlines consent collection, real-time record access, and policy enforcement, empowering patients, enhancing transparency, and supporting healthcare organizations to improve care, compliance, and outcomes while safeguarding privacy and trust.

25. NOCD Inc

Headquarters: Chicago, United States

Founded in: 2014

Key Products:  Virtual OCD Therapy, Exposure & Response Prevention (ERP), NOCD App Support, 24/7 In-App Assistance, Personalized Therapist Matching, Intensive OCD Treatment Programs, Community Support and Clinical Training Programs.

Website: Click Here

NOCD is transforming OCD care with expert-led therapy, real-time app support, and personalized treatment plans. Through live video sessions and evidence-based ERP methods, they make managing OCD easier, faster, and more effective. Committed to hope, accessibility, and lasting results, NOCD empowers individuals to regain control, overcome symptoms, and thrive in daily life.

26. Deep Genomics

Headquarters: Toronto, Canada

Founded in: 2014

Key Products: AI Workbench Platform, BigRNA & BigRNA+ (AI-driven RNA Therapeutic Discovery Tools) and Genetic Medicine Drug Programs

Website: Click Here

Deep Genomics is a biotechnology company pioneering the use of artificial intelligence and RNA biology to discover and develop genetic medicines. Their proprietary AI platform decodes complex RNA data, identifies novel therapeutic targets, and accelerates the creation of life-changing treatments for rare and common genetic disorders. With offices in Toronto and Boston, Deep Genomics is shaping the future of precision genomic medicine globally.

27. PocDoc

Headquarters: Cambridge, United Kingdom

Founded in: ​2020

Key Products: HUESnap® platform, PocDoc App, PocDoc Pro, Healthy Heart Check, Digital CMR Disease Health Check Platform

Website: Click Here

PocDoc is a digital health platform transforming disease prevention with rapid, smartphone-based testing. It allows users to complete health assessments quickly using minimal samples. Leveraging advanced AI and proprietary technology, it delivers fast, accurate results along with personalized insights to support proactive health management and overall well-being.

28. Teal Health

Headquarters: California, United States

Founded in: 2020

Key Products: Teal Wand, Virtual consultations, Lab testing, Results portal and Follow-up care

Website: Click Here

Teal Health is redefining women’s wellness with the groundbreaking Teal Wand™, the first FDA-approved at-home cervical cancer screening device. Designed for comfort, accuracy, and convenience, it lets women screen themselves from home, no speculum required. Blending innovation with empathy, Teal Health empowers women to take charge of their health.

29. Senti.care

Headquarters:  Liverpool, United Kingdom

Founded in: 2017

Key Products: Large Biosignal Model (LBM), Respiratory Wearable Device, Arthritect System and Bitbaby Monitor

Website: Click Here

Senti.care is redefining healthcare diagnostics with its groundbreaking Large Biosignal Model (LBM), an AI technology that decodes the body’s complex signals to detect diseases early and accurately. By partnering with medical device innovators, Senti enables proactive, data-driven healthcare from respiratory monitoring to rheumatoid arthritis and fetal wellbeing  shaping a future of smarter, life-saving medicine.

30. Persist AI

Headquarters: California, United States

Founded in: 2022

Key Products: Cloud Lab, Formulation Development, Commercial cGMP Manufacturing and Analytics Support 

Website: Click Here

Persist AI is revolutionizing drug formulation through its powerful combination of artificial intelligence and robotics. Its innovative Cloud Lab enables scientists to design and run experiments remotely, achieving up to 10x faster formulation discovery. By integrating automated manufacturing, analytical support, and predictive AI tools, Persist AI accelerates pharmaceutical development from molecule to market with precision and efficiency.

31. PhaseV

Headquarters: West Sacramento, California

Founded in: 2023

Key Products: AI-powered Clinical Trial Optimization suite, Causal-ML for HTE, Causal Disease Modeling, Clinical Operations Analytics, ML Early-Derived Endpoint Identification, Trial Optimizer platform

Website: Click Here

PhaseV combines machine learning for causal analysis and generative AI to bring about a change in clinical development. The biopharma sponsors and CROs can effectively design adaptive trials, analyze real-world data, and make the most of the outcomes with the help of such a strong platform. By integrating AI, analytics, and domain knowledge, PhaseV speeds up the drug development process, cuts down on expenses, and improves the quality of treatment.

32. Variational AI 

Headquarters: Vancouver, Canada

Founded in: 2019

Key Products: Enki™ Generative AI Platform, Multi-Objective Optimization Engine and AI-Driven Lead Generation Tools

Website: Click Here

Variational AI is a company that relies entirely on the use of generative AI for the discovery of small molecules. Its goal is to change the very foundation on which biopharma companies create therapeutics, thus speeding up the innovation process, cutting down costs and increasing the number of patients who can access new treatments. Variational AI combines its efforts with those of worldwide partners to investigate uncharted chemical spaces concerning cancer and other therapeutic areas that are in high demand.

33. Carta Healthcare

Headquarters: California, United States​

Founded in: 2017​

Key Products: Atlas, Lighthouse, Navigator, Harbor, Voyager, Expert Clinical Data Abstraction, AI-powered analytics, AI for clinical trial optimization and Custom AI solutions

Website: Click Here

Carta Healthcare integrates the data operations of hospitals and clinics using AI-based platforms to automate the processes of registry abstraction, quality reporting, and information analytics. The Atlas solution offered by them supports compliance, research, and measurement of patient outcomes, thereby changing the course of complex workflows and enhancing the operational efficiency of healthcare institutions. 

34. Plenful

Headquarters: California, United States​

Founded in: 2021​

Key Products: 340B Audit & Missed Savings, Intake Authorization Management, Rx & Medical Prior Authorization, Intelligent Document Processing and Pharmacy Revenue Cycle & Reporting

Website: Click Here

Plenful is a provider of automation tools for the healthcare sector that take over the bulk of administrative tasks like document scanning, claims processing, and reporting. Machine learning is employed on their platform to reduce the amount of manual work, thereby assisting the providers in cutting down on costs and concentrating more on patient care. The tools offered by Plenful can be integrated with the already existing systems for a hassle-free expansion.

35. Infinitus Systems

Headquarters: San Francisco, United States​

Founded in: 2019​

Key Products: Products and Services: FastTrack, Model Context Protocol (MCP) Server, Healthcare Automation, Patient Engagement, Provider Support, Output Extraction

Website: Click Here

Infinitus Systems is a company that creates robots that are powered by AI and communicate with humans. The VoiceRPA that they offer simplifies the whole process of billing, insurance and provider coordination, assuring compliance, and releasing workers from oral communication that is tedious and time-consuming. Infinitus not only facilitates operations but also lowers the rate of human mistakes.​

36. Thatch

Headquarters: San Francisco, United States

Founded in: 2021

Key Products: ICHRA-based Health Benefits Platform, Thatch Marketplace, Platform API, Thatch Visa Card and AI-powered Thatchbot assistant

WebsiteClick Here

Thatch is a cutting-edge health benefits platform that allows employers to give employees personalized, flexible health care options based on ICHRA through a simple budgeted system. Setting a basic limit, businesses permit their workers to pick out the insurance coverage, wellness services, and medical expenses that suit them best. Thatch makes healthcare simple, open, and centered around the employees.

37. CureMetrix

Headquarters: California, United States​

Founded in: 2014​

Key Products: AI-based Breast Cancer Screening, cmTriage and cmAssist Imaging Analytics​.

Website: Click Here

CureMetrix adopts a major approach by boosting mammography reading through state-of-the-art artificial intelligence (AI) analytics. Their FDA-cleared cmTriage and cmAssist solutions yield higher breast cancer detection rates, thus cutting down the amount of false positives and, as a result, improving patient outcomes. CureMetrix works alongside radiology centers in order to promote screening based on scientific evidence.

38. Maven Clinic

Headquarters: New York, United States​

Founded in: 2014​

Key Products: Virtual Women’s and Family Health Clinics, Fertility Tracking and Maternity Care​

Website: Click Here

Maven Clinic is an international telemedicine platform aimed at women and families that covers all stages of reproductive, fertility, pregnancy, and parenting journeys. Patients are linked to skilled health care professionals through the virtual clinics, and thus can benefit from critical support and wellness resources. The perinatal, postnatal, and parenting pathways are supported through the seamless care coordination that is made available for diverse needs.

39. Fortuna Health

Headquarters: New York, United States

Founded in: 2023

Key Products: Digital Platform, Eligibility And Enrollment, Renewal Assistance, Consumer Support, Provider And Health Plan Visibility

Website: Click Here

Fortuna Health opens up the way to government-paid health care by means of an online, fast-paced, and personalized experience. It supports the consumers during the whole process of determining eligibility, signing up, and renewing, while also eliminating the barriers mentioned above, such as lengthy paperwork, unreceived notices, and different languages. The company gives priority to access, efficiency, and support for various groups in Medicaid programs.

40. NURX

Headquarters: California, United States​

Founded in: 2015​

Key Products: Telehealth Prescriptions, Birth Control, STD Testing Kits and PrEP for HIV​.

Website: Click Here

Nurx offers a complete online platform that provides personalized, specialty-level healthcare for women. Providing easy, affordable, and direct-to-consumer care for reproductive health, mental health, weight management, dermatology, and more, Nurx is a combination of licensed physicians, customized treatment plans, and home delivery to make sure that healthcare is affordable and patient-centric.

41. Dula AI

Headquarters: Tampa, Florida

Founded in: 2020

Key Products: Diabetes Care Kit, Respiratory Care Kit, Cardiac Care Kit, Chronic Care Kit, Pregnancy Care Kit, Employee Wellness Kit, Remote Monitoring, Metabolic Tracking, FoodVision™, AI Health Coaches, Wellness Support

Website: Click Here

Dula AI is a revolutionary healthcare startup that integrates artificial intelligence in preventive care and remote patient monitoring. It facilitates chronic care management by means of providing personalized care kits, health tracking, and wellness support administration. By linking up the health data coming in real-time, the AI direction, and the family connection, Dula makes it possible for people to take charge of their wellness in a proactive manner and live balanced and healthy lives. 

42. Mendaera

Headquarters: California, United States​

Founded in: 2020

Key Products: Robotics-assisted Healthcare Devices and Intelligent Procedural Support​.

Website: Click Here

Mendaera is a company that is developing robotic tools to assist doctors in their procedures while at the same time using AI and machine vision to ensure accuracy and safety. Their products are facilitating the delivery of high-quality interventions across the board from diagnostics to therapeutics and also making it possible to deliver care through minimally invasive techniques. Mendaera is pushing the boundary where robotics meet the medical field.

43. Fay

Headquarters: Chicago, United States

Founded in: 2022​

Key Products: Digital Platforms for Women’s Pelvic Health and Therapy Coordination​ Services

Website: Click Here

Fay is a women's health startup that provides a digital therapy management and care navigation solution for treating pelvic health issues. Their technology offers not only educational materials but also access to healthcare professionals and a monitoring facility thus encouraging personalized recovery and empowerment among the users. Fay is making a positive difference in the areas of gynecology and pelvic wellness. 

44. BenchSci

Headquarters: Ontario, Canada​

Founded in: 2015​

Key Products: AI-powered Reagent Selection Platform and ASCEND Drug Discovery Software​

Website: Click Here

BenchSci offers cutting-edge machine learning technology for preclinical research that not only enhances scientists' workflows through transparency but also accelerates their work. The advanced AScEND platform is capable of making sense of intricate biological data, besides guiding drug makers in the selection of antibodies, reagents, and biomarkers for the research into diseases. BenchSci's goal is to be the stimulator of speedy drug development along with decreased costs and unshackled innovation in the field of biomedicine. 

45. Human Longevity Inc

Headquarters: California, United States​

Founded in: 2013​

Key Products: HLI Knowledgebase, Health Nucleus, Whole Genome Sequencing and Precision Health Analytics

Website: Click Here

Human Longevity Inc. is a company that provides personalized health insights and preventive care by combining genomics, imaging, and AI-driven analytics. The Health Nucleus program of the company combines whole genome sequencing along with advanced diagnostics thereby enabling early detection and risk assessment for various diseases. The company’s innovative approach aims to extend healthy human lifespan by revolutionizing clinical decision-making.​

46. Assort Health 

Headquarters: San Francisco, California

Founded in: 2023

Key Products: Specialty-Specific Agentic AI, 24/7 Appointment Management, Provider Triage & FAQ, Lab Results & Prescription Refills, Billing & Payment Support, AI Copilot, Bespoke Workflow Automation

WebsiteClick Here

Assort Health is revolutionizing the way healthcare connects with patients. Its powerful Agentic AI platform blends empathy with intelligence to handle complex medical communications effortlessly. From scheduling appointments to managing care workflows, Assort ensures every interaction feels personal, efficient, and human. By empowering providers with smart automation, the company is shaping the future of patient-centered healthcare.

47. Huma

Headquarters: London, United Kingdom​

Founded in: 2011​

Key Products: Remote Patient Monitoring, Digital Health Platform and Clinical Trial Tools

Website: Click Here

Huma is a company that creates digital tools aimed at empowering healthcare professionals and the pharmaceutical sector to keep an eye on patients from a distance. Besides, the app gathers patients' health data for research purposes, monitoring chronic diseases, and hospital-at-home applications. Huma's technology boosts patient participation, care coordination, and global access to tailored therapies.

48. Truveta

Headquarters: Washington, United States​

Founded in: 2020​

Key Products: Truveta Platform, Real-World Data Analytics and AI-Driven Medical Insights

Website: Click Here

Truveta Studio is a state-of-the-art health data and analytics platform that can track patient care and outcomes as they happen. It uses AI-powered analytics, de-identified clinical data, and collaborative tools to facilitate the work of researchers, healthcare providers, and organizations in speeding up the process of making discoveries, improving the patients, and driving the whole healthcare sector towards the latter's innovation based on the data solutions that are trusted and transparent.

49.  Ellipsis Health

Headquarters: San Francisco, California

Founded in: 2017

Key Products: Sage AI™, Care Management Platform, Automated Patient Outreach, EMR & CRM Integration Solutions and HIPAA-Compliant Healthcare Automation

Website: Click Here

Ellipsis Health is a company that uses AI to make healthcare delivery better, allowing the patients to be more involved, the operations to be faster, and the providers to have commercial-grade, kind and understanding solutions. By the care management improvement strategy, the company mixes the highest degree of innovation with the security of human-centered technology to not only help the healthcare organizations but also the patients in getting better outcomes, more efficiency, and more compassionate experiences.

50.   SafelyYou

Headquarters: San Francisco, California

Founded in: 2015

Key Products: SafelyYou Safety AI™, SafelyYou Staffing AI™, SafelyYou Wellness AI™ and SafelyYou Guardian™ Devices

Website: Click Here

SafelyYou is a company that uses AI to transform senior care along with its clinical expertise, thus boosting the safety and well-being of elderly people. Its groundbreaking method not only keeps accident occurrences at bay, but also backs up the health of the entire community and forces the caregivers to perform their duties in a safer, more efficient and high-quality manner.

Conclusion 

The digital health landscape of 2025 showcases remarkable innovation across diagnostics, telemedicine, mental health, and genomics. These 50 startups are dismantling traditional healthcare barriers through AI-powered solutions, remote monitoring, and precision medicine, making quality care more accessible and affordable worldwide.

As these companies continue scaling their technologies, they're not just improving individual patient outcomes, they're fundamentally reshaping healthcare delivery. The future promises even greater integration of AI, personalized treatment, and preventive care, creating a more proactive, efficient, and patient-centered healthcare ecosystem.

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